@article{pmid42628338,

title = {Effects of probiotic supplementation on sleep and psychological outcomes in adults with mild-to-moderate insomnia symptoms and work-related stress: A randomized, placebo-controlled, double-blind trial},

author = {Sylvie Binda and Noémie Auclair-Ouellet and Ola Kassem and Hans Ivers and Roumen Milev and Manon Lamy and Sijing Chen and Marie-Laure Oula and Charles M Morin},

doi = {10.1016/j.sleep.2026.109223},

issn = {1878-5506},

year  = {2026},

date = {2026-12-01},

journal = {Sleep Med},

volume = {148},

pages = {109223},

abstract = {This study aimed to investigate the effects of the Cerebiome® probiotic supplement on mild to moderate insomnia symptoms associated with work-related stress. Using a randomized, placebo-controlled, double-blind, parallel design, adults aged 18-65 with mild to moderate insomnia symptoms but no diagnosis of mental disorder or severe psychosocial distress, were randomized at a 1:1 ratio to receive probiotics or placebo daily for 12 weeks. The primary outcome was a reduction of the Insomnia Severity Index score at the end of the intervention. Secondary outcomes included changes in psychological symptoms, sleep quality, work activity, quality of life, and biological measures. Seventy participants (43 women; 43.9 ± 9.3 years) were randomly allocated to probiotics (n = 35) or placebo (n = 35). At week 12, both groups had a significant reduction in insomnia severity compared to baseline (probiotics: -5.2 [-6.8 to -3.6], p < 0.0001, d = 1.55; placebo: -5.5 [-7.1 to -3.9], p < 0.0001, d = 1.63), with no significant between-group difference (p = 0.82, d = 0.08). The probiotics group showed a significant improvement on the PHQ-9 (depressive symptoms) at week 12 (-1.5 [-2.4 to -0.5], p = 0.0043, d = 0.71), with a significant difference between groups (p = 0.05, d = 0.51). There was no difference in the number of adverse events and no severe adverse events. Twelve weeks of supplementation with Cerebiome® in participants with insomnia symptoms associated with work-related stress led to a significant improvement in mood but not in insomnia symptoms when compared to placebo. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT04767997, registered on February 19th, 2021.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42840814,

title = {Peripheral nerve field stimulation for chronic low back pain: a systematic review},

author = {Reza Hazrati and Elie Ruest and Baraa Dabboucy and Sobee Dansereau and Chloe Salamon and Shirley Fecteau and Michel Prudhomme},

doi = {10.1097/PR9.0000000000001488},

issn = {2471-2531},

year  = {2026},

date = {2026-12-01},

journal = {Pain Rep},

volume = {11},

number = {6},

pages = {e1488},

abstract = {Chronic low back pain (CLBP) presents a major challenge in pain management, often persisting despite standard therapies. Peripheral nerve field stimulation (PNFS), also known as subcutaneous stimulation, offers a minimally invasive neuromodulation approach that may improve outcomes for these patients. This systematic review evaluates the evidence on PNFS, alone or combined with spinal cord stimulation (SCS), for CLBP, focusing on pain relief, functional outcomes, and safety. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, databases including Cochrane, Embase, MEDLINE (PubMed), and the Université Laval Library were searched for studies from January 2014 to April 2025. Nineteen studies (randomized controlled trials, cohort studies, and case series) were included. Outcomes assessed included pain intensity, disability (Oswestry Disability Index), quality of life (36-Item Short Form Health Survey, EuroQol 5-Dimension), and adverse events. Across study-level estimates, PNFS monotherapy most commonly produced approximately 40% to 60% reductions in pain intensity, although reported effects varied across studies and were not pooled because of heterogeneity. Functional gains included reduced disability and improved mobility. Quality of life measures and medication use often improved. Peripheral nerve field stimulation combined with SCS yielded mixed results, providing benefits particularly for patients unresponsive to SCS alone. Reported complication rates were generally modest, with infections and lead migrations being the most common. Peripheral nerve field stimulation appears to be a promising and generally well-tolerated option for selected patients with CLBP, although evidence certainty remains limited, and larger controlled studies are needed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42448053,

title = {Mentalizing trauma and emotion regulation differentiate resilient and vulnerable profiles in pregnant women exposed to childhood maltreatment},

author = {Maxime Legendre and Julia Garon-Bissonnette and Annie Lemieux and Roxanne Lemieux and Dominick Gamache and Nicolas Berthelot},

doi = {10.1016/j.jad.2026.122267},

issn = {1573-2517},

year  = {2026},

date = {2026-11-01},

journal = {J Affect Disord},

volume = {413},

pages = {122267},

abstract = {METHODS: RESULTS: CONCLUSIONS.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42863914,

title = {"It takes us out of our daily lives": Lived experience and healthcare provider perspectives on virtual nature travel during psychiatric hospitalization},

author = {L Dupont and M Lepage and S Couture and D Raucher-Chéné and N Mercier and C Voyer and P Beauchamps and E Thibaudeau},

doi = {10.1016/j.apnu.2026.152220},

issn = {1532-8228},

year  = {2026},

date = {2026-10-01},

journal = {Arch Psychiatr Nurs},

volume = {64},

pages = {152220},

abstract = {BACKGROUND: Psychiatric hospitalizations can be highly stressful and may offer limited opportunities for meaningful, recovery-oriented interventions. Immersive virtual reality (VR) may provide accessible leisure and social experiences, but little is known about how hospitalized individuals and healthcare providers perceive its use in inpatient psychiatric care.nnMETHODS: Semi-structured qualitative interviews were conducted with hospitalized individuals (n = 29) and online surveys were collected from healthcare providers (n = 7), following the implementation of Toujours Dimanche, an immersive virtual-nature travel application with a social component, on an inpatient unit for complex mood disorders. Thematic analyses were conducted.nnRESULTS: Participants described the application as a temporary break from the experience of psychiatric hospitalization that provided stimulation, emotional respite, social connection, and opportunities to reconnect with life beyond the unit. Although hospitalized individuals and healthcare providers generally viewed the service positively, they identified several conditions affecting its sustained implementation, including perceptions of patient suitability, limited staffing and space, and uncertainty regarding the value of recovery-oriented benefits in the absence of demonstrated symptom improvement.nnCONCLUSION: Virtual nature travel was perceived as a meaningful adjunct to inpatient psychiatric care. Its sustainable integration may depend on adequate institutional resources and greater recognition of well-being and recovery-oriented outcomes as legitimate aims of hospitalization.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42248312,

title = {Antisense-mediated gene therapy targeting DMPK restores cardiac ion channel function and electrical stability in myotonic dystrophy type 1},

author = {Marion Pierre and Fabien Sourisseau and Dominic Jauvin and Valérie Pouliot and Michele Carrer and Paymaan Jafar-Nejad and Mohamed Boutjdir and Mohamed Chahine},

doi = {10.1016/j.hrthm.2026.06.003},

issn = {1556-3871},

year  = {2026},

date = {2026-10-01},

journal = {Heart Rhythm},

volume = {23},

number = {10},

pages = {e2543--e2554},

abstract = {BACKGROUND: Myotonic dystrophy type 1 (DM1) is characterized by toxic RNA gain of function leading to cardiac conduction defects and life-threatening arrhythmias. Current therapeutic options remain limited.nnOBJECTIVE: We evaluated the molecular and electrophysiological efficacy of IONIS-486178, an antisense oligonucleotide (ASO) targeting mutant DMPK transcripts in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) generated from a patient with DM1.nnMETHODS: DM1 hiPSC-CMs were treated with IONIS-486178 for 24 hours. Efficacy was assessed using reverse transcription quantitative polymerase chain reaction for DMPK knockdown and splicing analysis, fluorescence in situ hybridization for nuclear foci quantification, western blot for ion channel protein expression, and whole-cell patch clamp for ionic currents and action potential characterization.nnRESULTS: Treatment of hiPSC-CMs with IONIS-486178 (5 μmol/L) achieved ∼90% DMPK knockdown, reduced toxic nuclear foci, and corrected SCN5A mis-splicing toward the adult isoform. Functionally, IONIS-486178 fully restored all ionic currents (sodium, L-type calcium, and potassium currents) reduced in DM1 hiPSC-CMs. This electrophysiological rescue correlated with re-expression of the corresponding ion channel proteins. The treatment also normalized action potential kinetics and durations and significantly reduced the incidence of arrhythmogenic events.nnCONCLUSION: ASO-mediated suppression of DMPK is sufficient to reverse core electrophysiological defects and reduce arrhythmogenic events in a human cellular model of DM1. These findings validate the biological rationale of targeting DMPK to prevent DM1-associated cardiac complications, supporting the continued development of next-generation ASO delivery platforms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42370774,

title = {Healthcare Pattern of Use Before and After Initiating a Long-Acting Antipsychotic Among a Cohort of 6221 Patients With a History of Psychosis},

author = {Emmanuel Stip and Josiane Courteau and Sébastien Brodeur and Yohann M Chiu and Marie-Josée Fleury and Alain Lesage and Marc-André Roy},

doi = {10.1177/07067437261462697},

issn = {1497-0015},

year  = {2026},

date = {2026-10-01},

journal = {Can J Psychiatry},

volume = {71},

number = {10},

pages = {792--805},

abstract = {ObjectiveTo evaluate changes in antipsychotic treatment patterns and healthcare utilization before and after initiation of long-acting injectable antipsychotics (LAI-APs) in a large Québec population cohort, comparing individuals with schizophrenia (SCZ) to those with other psychotic disorders (non-SCZ).MethodWe conducted a retrospective cohort study using linked Québec administrative databases (RAMQ, MED-ECHO, and public drug insurance) to identify 6,221 adults who initiated a LAI-AP between April 2013 and December 2016, after a 12-month LAI-free period. Participants were followed for 12 months before and after the index date. The cohort was stratified into SCZ and non-SCZ, and were further divided by regimen at initiation (LAI only; LAI + clozapine; LAI + other oral antipsychotic). Antipsychotic exposure and health-service usage (hospitalizations, emergency visits, outpatient and community care) trajectories were analyzed weekly using state-sequence analysis; pre- versus post-initiation comparisons used paired statistical tests.ResultsOf 6,221 patients (63.4% male; mean age 41.6 years), initial treatments consisted of paliperidone LAI (55.7%), aripiprazole LAI (21.5%), risperidone LAI (6.9%), first-generation LAI (15.6%), and LAI combinations (0.2%); 40% received LAI only, 5% LAI + clozapine, 55% LAI + an oral antipsychotic. SCZ patients were more often male, economically disadvantaged, and more likely to receive clozapine. After LAI initiation, hospital days fell sharply by almost 70% and outpatient and community-care visits increased substantially. Use of oral antipsychotics decreased overall post-initiation, except for clozapine (which rose) and first-generation oral drugs (which remained stable).ConclusionsIn this real-world Québec cohort, LAI-AP initiation was followed by a marked reduction in hospitalizations and a shift toward outpatient and community care, regardless of diagnosis. Observed differences in sociodemographic and clinical profiles between SCZ and non-SCZ patients-and among SCZ treatment subgroups-suggest the need for tailored care pathways. These findings support LAI-AP effectiveness in reducing healthcare utilization and inform resource planning.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42413136,

title = {Psychologists' and patients' views on empathy in teletherapy: A mixed-methods study},

author = {Audrey Marcoux and Frédéric Grondin and Marie-Hélène Tessier and Philip L Jackson},

doi = {10.1016/j.pec.2026.109765},

issn = {1873-5134},

year  = {2026},

date = {2026-10-01},

journal = {Patient Educ Couns},

volume = {151},

pages = {109765},

abstract = {OBJECTIVE: Empathy is key to successful psychotherapy. However, how it is experienced and communicated in teletherapy remains poorly understood despite the widespread use of this modality. The current study compared how psychologists and patients view empathy and its communication in teletherapy.nnMETHODS: A convergent mixed-methods design was used with separate samples of psychologists (n = 92) and adult patients (n = 80) who completed online questionnaires on empathy, alliance, telepresence, and attitudes, along with open-ended questions on empathy and its communication. Quantitative and qualitative strands were merged through a side-by-side joint display analysis.nnRESULTS: Patients perceived significantly more empathy than psychologists reported feeling during teletherapy. Psychologists found videoconference therapy to be more demanding, particularly due to technical issues and unfamiliarity. Patients more strongly believed that telepresence and a strong alliance help compensate for the shortcomings of this modality. Despite these differences, members of both groups broadly agreed on the definition of empathy and on the best ways to communicate it during teletherapy, identifying compensatory strategies and key markers of empathy.nnCONCLUSIONS: Although they shared similar views on empathy, patients rated their psychologists as more empathic than psychologists rated themselves in teletherapy. This pattern emerged at a time when this modality was being rapidly integrated into clinical practice, and both samples had limited experience with it. These findings reinforce the value of this modality and highlight the need to support clinicians unfamiliar with it.nnPRACTICE IMPLICATIONS: Understanding how patients interpret empathy can help psychologists tailor their communication to meet those expectations. Training and peer support could help reduce psychologists' perceptions of added burden and better target the skills that strengthen empathic communication in teletherapy. Priorities include using salient nonverbal cues, making explicit verbal checks, inviting routine patient feedback, and allowing more time to build attunement to patient expectations.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42829142,

title = {The neural architecture of first-person moral choice: a demand-dependent working model},

author = {Alana Arrouet and Jennifer Chandler and Steven Laureys and Roxane S Hoyer},

doi = {10.1016/j.neubiorev.2026.107017},

issn = {1873-7528},

year  = {2026},

date = {2026-10-01},

journal = {Neurosci Biobehav Rev},

volume = {191},

pages = {107017},

abstract = {First-person moral choice may require the coordination of norm-relevant, self-relevant, affective, and outcome-related information. This narrative review integrates neuroimaging and electrophysiological evidence into a network-informed temporal working model organized around integrative demand: the extent to which multiple, potentially competing constraints must be represented and coordinated. The model distinguishes four candidate functional contributions: salience-related orienting, posterior default-mode/medial-temporal self-relevant situation construction, executive-control/frontoparietal comparison when competing rules, anticipated consequences, or response options must be actively maintained, and ventromedial-prefrontal value integration. Rather than forming a fixed cascade, these contributions may overlap, recur, and interact dynamically, with their relative involvement depending on task structure and integrative demand. Neuroimaging findings document task-dependent regional effects and, in a small number of studies, network interactions, while event-related potentials and oscillatory dynamics constrain the timing of salience-sensitive, conflict-sensitive, mnemonic, evaluative, and response-related processes. Together, these findings motivate a temporally structured but flexible account in which first-person moral choice emerges from changing coordination among domain-general processes rather than from a dedicated moral network or universal sequence. The model generates testable predictions for paradigms that manipulate integrative demand while controlling arousal, difficulty, and response requirements, and that combine event-specific electrophysiology with anatomically constrained connectivity measures. Together, these predictions provide a path toward testing how distributed neural dynamics contribute to first-person moral choice.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42855340,

title = {Investigating the Effects of Amateur Singing on Speaking Voice Quality, Function, and Motor Control Across Adulthood},

author = {Amélie Nadeau and Pascale Tremblay and Maude Desjardins},

doi = {10.1016/j.jvoice.2026.09.019},

issn = {1873-4588},

year  = {2026},

date = {2026-10-01},

journal = {J Voice},

abstract = {OBJECTIVES: Singing is an accessible activity that may promote vocal health, including vocal function, quality, and motor control. However, evidence remains limited and heterogeneous, as some studies have shown an association between singing practice and dysphonia-related complaints in certain populations. This study investigated whether amateur singing practice influences adult speaking voice outcomes related to function, quality, and motor control, and whether it may moderate age-related vocal changes.nnMETHODS: Participants were 143 French-speaking adults (20-98 years; 72 singers, 71 non-singers). Amateur singers were defined as individuals singing in a choir for at least two years with a minimal weekly practice of 60 minutes. Vocal function and quality were assessed using the Dysphonia Severity Index, Acoustic Voice Quality Index, speaking habitual intensity, and perceptual judgment of overall severity. Voice Onset Time (VOT) and its variability during a diadochokinetic task were used as proxies for vocal motor control. Linear and mixed-effects regression models tested the main effects of group (singers/non-singers), age, and their interaction, while controlling for relevant variables.nnRESULTS: Singers exhibited higher harmonic-to-noise ratios and lower shimmer values than non-singers. Age predicted lower maximal fundamental frequency values, independent of singing status. A moderating effect of singing was found for overall severity ratings, showing a trend toward better perceptual vocal quality in younger and middle-aged singers, but not in older singers, resulting in a steeper association between age and overall severity among singers. Interactions also revealed differential associations between VOT and age in singers compared to non-singers for specific consonants, suggesting potential differences in laryngeal-articulatory coordination between groups.nnCONCLUSION: Findings suggest that amateur singing is associated with specific acoustic and perceptual benefits, although some of these associations may not be found in older adults. Longitudinal studies are needed to clarify the potential benefits of amateur singing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42853430,

title = {Intricate mesoscale organization of the anterior commissure in the rhesus monkey, with implications for neuroimaging},

author = {Kathleen S Rockland and Martin Parent and Silas Botham and Alvaro Duque},

doi = {10.1007/s00429-026-03199-1},

issn = {1863-2661},

year  = {2026},

date = {2026-10-01},

journal = {Brain Struct Funct},

volume = {231},

number = {8},

abstract = {The anterior commissure (AC) is generally identified as one of the major interhemispheric pathways. Anatomical results, however, indicate that it has significant ipsilateral components. Further, as reported here, the ipsilaterally projecting axons are organized as a system of narrow, quasi-parallel stripes, especially prominent at the transverse decussation. These appear as a medio-lateral array in coronal tissue sections, but at higher magnification can be seen to consist of axonal segments aggregated in an obliquely anterior-posterior (AP) trajectory. This is counter-oriented to the interstripe surround. For the rhesus macaque, we present evidence that individual stripes align in a 3D volume as thin AP oriented sheets or lamellae. The stripelike pattern in coronal sections is easily identified at early prenatal developmental stages (E70, by acetylcholinesterase), well before the onset of myelination in the AC, possibly pointing to a significant molecular influence underlying the stripelike formation. The functional significance of this non-homogeneous organization remains to be established but may in part relate to a segregation of glutamatergic interhemispheric pathways and transmitter-mixed, non-glutamatergic ipsilateral components. Given this, the AC is better viewed as an interhemispheric pathway only at the midline, but otherwise as a mixed ipsi- and contralateral pathway. The segregation of the stripe/interstripe systems and the absence of the ipsilateral component at the midline is relevant for evaluating volumetric and other changes in the AC over lifespan, in pathological conditions, and for interpreting and designing connectivity studies. The complex mesoarchitecture and pronounced lateral vs. midline subdivision need to be taken into consideration in neuroimaging studies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42841761,

title = {Development, Normative Data, and Psychometric Properties of the Turkish Semantic Association Test (SEMAT) for Middle-Aged and Older Adults},

author = {Samet Tosun and Fenise Selin Karalı and Joël Macoir},

doi = {10.1002/brb3.71833},

issn = {2162-3279},

year  = {2026},

date = {2026-10-01},

journal = {Brain Behav},

volume = {16},

number = {10},

pages = {e71833},

abstract = {PURPOSE: Semantic associative processing is essential for language, cognition, and communication and is frequently impaired in neurodegenerative disorders. However, no brief Turkish instrument currently assesses semantic associations across both abstract and concrete conceptual domains. This study aimed to develop the Turkish Semantic Association Test (SEMAT), establish normative data, and examine selected psychometric properties.nnMETHOD: The SEMAT was developed using stimuli representing abstract, biological, and manmade concepts. Face validity was evaluated through expert review and pilot testing. Normative data were obtained from 365 cognitively healthy Turkish-speaking adults aged 53-82 years. Demographic effects were examined using multiple regression analyses, with age, education, and sex entered simultaneously as predictors. Given the bounded, negatively skewed score distributions and substantial ceiling effects, empirical percentile-based norms were generated. Internal consistency and convergent validity were assessed using semantic measures from the Batterie d'Évaluation Cognitive du Langage (BECLA-Tr). Item-level difficulty and discrimination were also examined.nnFINDINGS: Educational attainment was the only demographic variable independently associated with performance across all SEMAT scores, supporting education-adjusted norms. The SEMAT demonstrated excellent internal consistency (Cronbach's α = 0.88; McDonald's ω = 0.92). Significant correlations were observed between SEMAT scores and the BECLA-Tr semantic composite (ρ = 0.41-0.54, all p < 0.001), supporting convergent validity. Item-level analyses showed generally high accuracy and positive but variable discrimination across items.nnCONCLUSION: These findings indicate that the SEMAT is a brief, culturally appropriate, and psychometrically sound measure of semantic associative processing with preliminary evidence of reliability and convergent validity and with education-adjusted normative reference data for cognitively healthy middle-aged and older Turkish-speaking adults.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42838214,

title = {A novel single-fish assay for ethanol self-administration in zebrafish},

author = {Léa Morneau and Léa Gagné and Randall T Peterson and Gabriel D Bossé},

doi = {10.1016/j.pnpbp.2026.111967},

issn = {1878-4216},

year  = {2026},

date = {2026-10-01},

journal = {Prog Neuropsychopharmacol Biol Psychiatry},

volume = {150},

pages = {111967},

abstract = {Alcohol use disorder (AUD) is a significant public health concern. In Canada, about 18% of individuals aged 15 or older will meet the clinical criteria for AUD at some point in their lives (CAMH, 2023). Treatment options for AUD are limited, and the high relapse rates highlight the urgent need for innovative methods to study and address AUD. Zebrafish (Danio rerio) is an emerging model for exploring the neurobiological impacts of alcohol. Previous studies have demonstrated that zebrafish respond to the rewarding effects of alcohol, but most research methods rely on passive administration, such as immersion, which does not reflect the typical routes of alcohol intake in humans. We previously showed that zebrafish can learn to self-administer drugs of abuse in small groups and conditioned animals are displaying key features of substance abuse disorders. However, group-based conditioning limits our understanding of individual drug preference and intake profile. In this study, we improved upon our previous design by establishing an individual self-administration protocol to measure voluntary alcohol intake and model alcohol use disorder. In this novel assay, individual adult fish learn to discriminate between two zones to self-administer a 5% ethanol solution. Moreover, animals conditioned in this assay can perform progressive ratio and display signs of withdrawal upon cessation of ethanol intake. These results suggest zebrafish can develop ethanol abuse-like behaviour, providing a powerful platform to study genetic predisposition and screen for therapeutic compounds.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42841366,

title = {Training Status and Valsalva Maneuver Effects on Cerebrovascular Regulation during Acute Resistance Exercise},

author = {Elric Y Allison and Yixue Michelle Mei and Vanessa Mizzi and Taha Abbasi-Hashemi and Marc-Antoine Roy and Matin Borhani and Juliano Abreu and Patrice Brassard and Jeremy J Walsh and Stuart M Phillips and Baraa K Al-Khazraji},

doi = {10.1249/MSS.0000000000004163},

issn = {1530-0315},

year  = {2026},

date = {2026-10-01},

journal = {Med Sci Sports Exerc},

abstract = {BACKGROUND: Repeated exposure to large transient oscillations in mean arterial pressure (MAP)during resistance exercise may induce vascular adaptations and alter cerebrovascular regulation during systemic pressure challenges. This study characterized resting vascular and cerebrovascular function, the cerebral pressure-flow relationship during forced blood pressure oscillations, and cerebrovascular responses to leg press exercise with and without the Valsalva maneuver (VM) in resistance-trained and untrained individuals.nnHYPOTHESES: We hypothesized that resistance-trained individuals would exhibit higher arterial stiffness and similar cerebrovascular function at rest but improved cerebrovascular regulation during systemic pressure challenges.nnMETHODS: Forty-four healthy young adults [23 resistance-trained (12M,11F), 21 untrained (9M,12F)] completed two visits: (1) resting vascular and cerebrovascular assessment and quantification of the cerebral pressure-flow relationship via forced blood pressure oscillations; (2) assessment of systemic and cerebral hemodynamic responses during RE at 50%, 75%, and 90% 1RM. At 90% 1RM, participants performed leg press under coached breathing and VM conditions in a randomized order.nnRESULTS: No group differences were observed in resting cerebral hemodynamics, common carotid artery stiffness metrics, or cerebral pressure-flow relationship related responses. However, training effects were found for carotid-femoral pulse wave velocity (p=0.002; ηp²=0.23; untrained>trained), diastolic blood pressure (p=0.003; ηp²=0.24; untrained>trained), pulse pressure (p=0.004; ηp²=0.27; untrainedtrained). Despite higher MAPPeak in trained individuals (p=0.03; ηp²=0.19), cerebrovascular responses were similar or attenuated compared with untrained individuals. VM strain did not differ between groups, but VM use increased MAPPeak (p=0.04; ηp²=0.05) and middle cerebral artery (MCA) pulsatility index (p=0.005; ηp²=0.09), and reduced heart rate (p=0.03; ηp²=0.06).nnCONCLUSIONS: Habitual resistance training and breathing strategy both influence cerebrovascular responses, potentially helping preserve cerebral perfusion during systemic pressure challenges.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42830170,

title = {Secondary exploratory discrete wavelet analysis of the electroretinogram in adults with ADHD},

author = {Marie-Soleil Vallière and Marc-André Dubois and Marc Hébert},

doi = {10.1016/j.pnpbp.2026.111960},

issn = {1878-4216},

year  = {2026},

date = {2026-10-01},

journal = {Prog Neuropsychopharmacol Biol Psychiatry},

volume = {150},

pages = {111960},

abstract = {BACKGROUND: Conventional electroretinographic (ERG) analyses identified sex-specific retinal differences in adults with attention-deficit/hyperactivity disorder (ADHD). We applied the discrete wavelet transform (DWT) to the same recordings to characterize multiscale time-frequency features.nnMETHODS: ERGs from 25 adults with ADHD and 25 age- and sex-matched controls (16 female and 9 male pairs) were analyzed at seven flash intensities. Six DWT descriptors were extracted, and global scores averaged across intensities. Paired comparisons used false-discovery-rate correction. Secondary analyses examined intensity, sex, eyes, inter-eye agreement, within-session repeatability, current medication status, and exploratory classification.nnRESULTS: Global 40a and 20b values were lower in ADHD (Cohen's dz. = -0.63 and - 0.60; FDR q = 0.020 for both). Differences increased with flash intensity and had the same direction in female and male pairs and both eyes, without significant group × sex or group × eye interactions. Findings were stable across participant- and intensity based sensitivity analyses. Inter-eye ICC(A,1) was 0.750 for 40a and 0.865 for 20b; bilateral within-session ICC(A,1) values ranged from 0.839 to 0.981. Reductions were also present among the eight ADHD participants reporting no current ADHD medication use (dz = -0.74 and - 0.84). Exploratory leave-one-pair-out AUCs ranged from 0.653 to 0.731.nnCONCLUSIONS: DWT analysis identified lower 40a and 20b values as candidate retinal time-frequency features of ADHD. Their consistency across sensitivity analyses, sexes, eyes, medication strata, and repeated measurements supports prospective evaluation in independent, clinically characterized cohorts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42219699,

title = {Association of Prodromal Parkinson's Disease-Like Features in Long COVID With Dream-Enactment Behaviours},

author = {Siyi Gong and Yaping Liu and Bei Huang and Ngan Yin Chan and Eemil Partinen and Christian Benedict and Bjørn Bjorvatn and Ilona Merikanto and Luigi De Gennaro and Yves Dauvilliers and Brigitte Holzinger and Juliana Yordanova and Maria Korman and Cátia Reis and Anne-Marie Landtblom and Sergio Mota-Rolim and Michael R Nadorff and Frances Chung and Yuichi Inoue and Harald Hrubos-Strøm and Kentaro Matsui and Courtney J Bolstad and Pei Xue and Colin A Espie and Charles M Morin and Thomas Penzel and Giuseppe Plazzi and Markku Partinen and Yun Kwok Wing},

doi = {10.1111/jsr.70371},

issn = {1365-2869},

year  = {2026},

date = {2026-10-01},

journal = {J Sleep Res},

volume = {35},

number = {5},

pages = {e70371},

abstract = {Emerging evidence links COVID-19 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD-like features remains unclear, particularly in long COVID participants with dream-enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder. This study aimed to quantify the burden of prodromal PD-like features in long COVID. This online survey (May-Nov 2021) across 16 countries/regions included 11,261 participants. Data on demographics, COVID-19 diagnosis, long COVID symptoms, sleep features and other typical prodromal PD-like features were collected. The likelihood ratio (LR) of prodromal PD was calculated as a proxy for each participant's overall burden of prodromal PD-like features, based on the 2019 Movement Disorder Society research criteria. Participants with long COVID (n = 1155) exhibited more symptoms suggestive of prodromal PD-like features, including DEBs, olfactory dysfunctions, constipation, excessive daytime sleepiness, postural dizziness, depression with/without anxiety, urinary dysfunctions, cognitive impairment and a higher LR of prodromal PD when compared to non-COVID-19 participants and COVID-19 recoverees. Long COVID was associated with a 73% higher burden of potential prodromal PD-like features (adjusted odds ratio [aOR] = 1.73, 95% confidence interval [CI] = 1.57-1.90). Among those with long COVID, emergence or exacerbation of post-infection DEBs further increased this burden by 38% (aOR = 1.38, 95% CI = 1.19-1.60). Our study suggested that long COVID is associated with an increased burden of prodromal PD-like features, which appears to be further enhanced with DEBs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42120556,

title = {Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment},

author = {Claire André and Marc-André Bédard and Véronique Daneault and Rebekah Wickens and Olga Fliaguine and Jean-Paul Soucy and Serge Gauthier and Dominique Lorrain and Célyne Bastien and Carol Hudon and Nicola Andrea Marchi and Jacques Montplaisir and Nadia Gosselin and Julie Carrier},

doi = {10.1038/s41380-026-03635-y},

issn = {1476-5578},

year  = {2026},

date = {2026-10-01},

journal = {Mol Psychiatry},

volume = {31},

number = {10},

pages = {5508--5518},

abstract = {Cholinergic activity supports cortical activation during REM sleep, while other neurotransmitter systems are almost silent. Here, we tested the long-standing hypothesis that early cholinergic denervation may be associated with REM sleep EEG slowing in older adults. Twenty-four older participants without dementia (mean age: 71.29 ± 4.85 years; 58.33% women; 25% participants with amnestic Mild Cognitive Impairment) underwent a night of in-laboratory polysomnography, comprehensive neuropsychological evaluation, structural MRI and molecular PET imaging with [F]-Fluoroethoxybenzovesamicol (FEOBV) to quantify brain cholinergic innervation. Voxel-wise multiple regressions assessed the associations between REM sleep characteristics (i.e., REM sleep percentage, relative theta power and EEG slowing ratios, defined as [delta + theta]/[alpha + beta] power) and FEOBV-PET standard uptake value ratio maps, controlling for sex. Given that FEOBV uptake was higher in women compared to men, we also performed exploratory sex-stratified analyses adjusted for age. Higher REM sleep EEG slowing over frontal (F3-F4), central (C3-C4), parietal (P3-P4), occipital (O1-O2) and temporal (T5-T6) derivations was significantly associated with cortical cholinergic denervation, notably in fronto-parietal areas and the medial temporal lobe. Sex-stratified analyses showed that higher REM sleep EEG slowing ratios were associated with cholinergic denervation mainly in medial temporal regions in women, and neocortical regions in men. These findings suggest that global REM sleep EEG slowing may represent a sensitive marker of cortical cholinergic denervation in older adults without dementia, and may constitute a promising marker for early diagnosis and disease-modifying interventions in Alzheimer's disease.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42691323,

title = {A Chemigenetic Ca2+ Indicator Based on a Red Fluorescent Protein and a Synthetic Chelator},

author = {Shosei Imai and Wenchao Zhu and Robert E Campbell and Takuya Terai},

doi = {10.1021/acschembio.6c00209},

issn = {1554-8937},

year  = {2026},

date = {2026-09-01},

journal = {ACS Chem Biol},

abstract = {Fluorescent indicators are indispensable imaging tools for visualizing the spatiotemporal dynamics of biological processes. Red fluorescent indicators are in particularly high demand because they offer compatibility with existing green fluorescent indicators or optogenetic tools, and longer wavelength fluorescence has inherent advantages for biological applications. We previously described a chemigenetic indicator design that combines a green fluorescent protein and a synthetic chelator in an effort to combine the advantages of conventional protein-based biosensors and synthetic chemosensors. We now demonstrate that this chemigenetic design can be extended to red fluorescent proteins. Through screening of variants with a range of chromophore-chelator orientations, followed by directed evolution, we developed a red fluorescent calcium ion (Ca2+) indicator with 5.4-fold fluorescence intensity change when going from 0 to 39 μM Ca2+ with purified proteins. Although the functionality of the current version is lost when expressed in mammalian cells and the selectivity is low, these results establish this chemigenetic design as a strategy that can be extended to other fluorescent protein color variants.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40247614,

title = {Beyond the trained eye: An objective method to predict game sense in team sports},

author = {Daniel Fortin-Guichard and Kathryn Johnston and Thomas Romeas and Magdalena Wojtowicz and Jean Lemoyne and David L Mann and Simon Grondin and Joseph Baker},

doi = {10.1080/02640414.2025.2491976},

issn = {1466-447X},

year  = {2026},

date = {2026-09-01},

journal = {J Sports Sci},

volume = {44},

number = {17-18},

pages = {2266--2282},

abstract = {Talent identification in sports requires a prediction of how athletes will perform in the future based on a sample of their behaviors. Perceptual cognitive-skills or 'game sense' in sports jargon is important for performance, yet sport organizations lack objective and validated measures to predict it. This study aimed to establish the degree to which subjective evaluations of athletes' in-match perceptual-cognitive skills could be predicted by their performance on objective perceptual-cognitive tests. The perceptual-cognitive skills of 40 highly-trained ice-hockey players were assessed by their coaches and the results were compared with the athletes' performance on four laboratory perceptual-cognitive tasks (neuropsychological battery, multiple-object tracking, temporal occlusion, virtual reality). Athletes were also assessed by scouts throughout a hockey season and during small-sided games. Scout judgments best predicted coach rankings, with measures from small-sided games, neuropsychological battery, virtual reality and temporal occlusion improving prediction. Results suggest that adding perceptual-cognitive testing could help scouts better measure athletes during talent identification.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42350309,

title = {No effect of rhythmic visual stimulation on experimental pain perception},

author = {Nicolas Roy and Coralie Deslauriers and Thaliane Côté-Cazes and Audrey Etcheverry and Michel-Pierre Coll},

doi = {10.1097/j.pain.0000000000004044},

issn = {1872-6623},

year  = {2026},

date = {2026-09-01},

journal = {Pain},

volume = {167},

number = {9},

pages = {e441--e452},

abstract = {Brain oscillations, particularly in the alpha, beta, and gamma bands, have been implicated in pain perception through correlational studies. Rhythmic visual stimulation (RVS) offers a noninvasive method to experimentally manipulate these oscillations and examine their potential role in pain perception. We conducted 2 within-participant experiments to assess whether RVS is associated with changes in both acute pain perception and pain-related neural oscillations. In experiment 1, 41 participants received brief (13 seconds) RVS at alpha (10 Hz), beta (18 Hz), or gamma (42 Hz) frequencies, or an arrhythmic control stimulation, while experiencing calibrated thermal pain with concurrent electroencephalography (EEG) recordings. Despite a successful increase of neural oscillations at targeted frequencies confirmed by EEG, pain-evoked oscillatory responses remained unchanged across brief RVS conditions in alpha, beta, and gamma bands. To replicate previous findings, experiment 2 extended experiment 1 by using longer RVS durations and phasic pain stimuli. Forty-nine new participants underwent 10-minute RVS at either 10 Hz or a 1-Hz control before rating electrical or laser pain stimuli. Across the 2 experiments, using different stimulation protocols and pain modalities, we found no evidence that RVS was associated with changes in acute pain perception or pain-related neural oscillations, with Bayesian analyses providing strong evidence for the null hypothesis. These null findings contrast with some previous reports but align with emerging mixed evidence in the literature, suggesting that the effects of RVS on pain may be less robust or more context-dependent than initially proposed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42364506,

title = {Cardiac organoids bridge translational gaps in 3R-compliant safety testing},

author = {Cyrielle Jajkiewicz and Mohamed Chahine},

doi = {10.1016/j.scr.2026.104039},

issn = {1876-7753},

year  = {2026},

date = {2026-09-01},

journal = {Stem Cell Res},

volume = {95},

pages = {104039},

abstract = {Cardiotoxicity remains a leading cause of late-stage drug attrition and post-marketing withdrawal, underscoring persistent limitations in current preclinical safety assessment paradigms. Traditional animal models are constrained by interspecies differences in electrophysiology, ion channel composition, myocardial remodeling, and pharmacokinetics, while two-dimensional human induced pluripotent stem cel-derived cardiomyocytes (hiPSC-CMs) lack tissue-level, functional maturity, organization and multicellular complexity. These limitations create a translational gap between cellular assays and whole-organ physiology. Human cardiac organoids represent an emerging mesoscopic platform that bridges this gap by integrating three-dimensional architecture, electromechanical coupling, and multicellular interactions within a human genetic context. Unlike isolated cardiomyocytes, cardiac organoids support coordinated conduction, arrhythmic susceptibility, force generation, extracellular matrix remodeling, and emerging neurocardiac crosstalk. These properties position them as promising tools for implementing the 3Rs (Replacement, Reduction, Refinement) in early-stage cardiovascular drug development. This review critically evaluates the biological fidelity, functional capabilities, and disease modeling relevance of human cardiac organoids, and examines their potential integration into safety pharmacology frameworks. We propose that cardiac organoids constitute a critical intermediate layer between reductionist cellular systems and whole-organ models. Finally, we delineate the scientific and regulatory steps, including standardization and validation against established frameworks, required to transition them from exploratory research tools to robust platforms for predictive and ethically aligned cardiovascular safety assessments.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42418951,

title = {An appraisal of practice guidelines for early intervention services for psychosis: Using AGREE II (Appraisal of Guidelines for Research and Evaluation) to enhance the quality and trustworthiness of guidelines in the future},

author = {Manuela Ferrari and Nicole Pawliuk and Jai Shah and Amal Abdel-Baki and Phil Tibbo and Donald Addington and Marc-André Roy and Ridha Joober and Kevin MacDonald and Srividya N Iyer},

doi = {10.1016/j.schres.2026.06.005},

issn = {1573-2509},

year  = {2026},

date = {2026-09-01},

journal = {Schizophr Res},

volume = {295},

pages = {282--291},

abstract = {BACKGROUND: Early intervention services (EIS) for psychosis have expanded internationally. Yet, the quality of the guidelines to support and monitor them has never been evaluated. We therefore aimed to systematically appraise the quality of EIS guidelines.nnSTUDY DESIGN: We conducted a systematic review of grey literature websites, supplemented by guidelines identified in a prior scoping review. Eligible documents were guidelines focused on/with a section on early intervention or first episode psychosis. Two independent reviewers appraised each guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE II).nnSTUDY RESULTS: Thirty-two guidelines were included. Guidelines varied widely on scores for the AGREE II domains. Many scored high (≥70%) on Scope and Purpose (24/32; 75%) and Clarity of Presentation (22/32; 69%). Only 22% (7/32) scored well on Rigour of Development, primarily due to the lack of methods for evidence identification and appraisal. The lowest scoring domain was Applicability; only two guidelines scored ≥70%, while more than half provided no information on barriers or facilitators to implementation. Stakeholder involvement, especially from service users, was limited in developing EIS-specific guidelines. Guidelines performing consistently well were from large guideline development groups and used established evidence-grading methods.nnCONCLUSIONS: This first systematic appraisal shows that while many EIS guidelines clearly articulate aims and recommendations, substantial methodological and implementation gaps remain. Nonetheless, EIS guidelines score like others in psychiatry. Still, limited stakeholder engagement and applicability may impede consistent, evidence-based EIS delivery. Future guidelines should explicitly describe evidence-based review processes, integrate service user input, and use AGREE II-like tools to enhance their usability and impact.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42461675,

title = {Impact of acute mild and severe poikilocapnic hypoxia on dynamic cerebral autoregulation and its directional sensitivity in young healthy volunteers},

author = {Shahrzad Soleimani Dehnavi and Marc-Antoine Roy and Mahmoudreza Taghizadeh and François Billaut and Patrice Brassard},

doi = {10.1152/japplphysiol.00166.2026},

issn = {1522-1601},

year  = {2026},

date = {2026-09-01},

journal = {J Appl Physiol (1985)},

volume = {141},

number = {2},

pages = {561--577},

abstract = {Dynamic cerebral autoregulation (dCA) stabilizes cerebral blood flow (CBF) during rapid mean arterial pressure (MAP) changes and exhibits directional sensitivity (i.e., attenuated CBF responses to transient MAP increases compared with MAP decreases). Hypoxia may impair this regulatory capacity and promote CBF instability. Whether the severity of poikilocapnic hypoxia differentially influences dCA and its hysteresis-like pattern remains unclear. This study examines the impact of acute mild [fraction of inspired oxygen ([Formula: see text]= 0.16)], and severe ([Formula: see text] = 0.10) hypoxia, compared with normoxia ([Formula: see text]= 0.21), on dCA and its directional sensitivity. Twenty participants completed 6-min oscillatory lower body negative pressure (OLBNP) trials at 0.05 and 0.10 Hz in three distinct sessions, where MAP and middle cerebral artery mean blood velocity (MCAv) were continuously recorded. dCA and its hysteresis-like pattern were quantified using transfer function analysis (TFA) and directional sensitivity analysis [with time-adjusted ratios of relative MCAv to MAP changes calculated for each transition during MAP increases (RelMCAv/RelMAP) and decreases (RelMCAv/RelMAP)], respectively. Severe hypoxia increased MAP ( = 0.042) and MCAv ( = 0.013) power and decreased TFA phase ( = 0.026) at 0.05 Hz OLBNP compared with normoxia. Mild hypoxia did not influence dCA. Regardless of hypoxia severity, RelMCAv/RelMAP was lower than RelMCAv/RelMAP at 0.05 Hz ( = 0.007) and 0.10 Hz ( = 0.008) OLBNP. These results suggest that acute severe, but not mild hypoxia, impairs dCA at 0.05 Hz OLBNP, reflecting reduced buffering capacity of the cerebral circulation. Nonetheless, the hysteresis-like pattern of dCA observed in normoxia remains unaffected by hypoxia severity, suggesting distinct regulatory mechanisms for dCA and its directional sensitivity under hypoxic stress. Using a multimetric approach combining transfer function analysis with directional sensitivity metrics, we demonstrate that severe, but not mild, poikilocapnic hypoxia impairs dynamic cerebral autoregulation, whereas preserving its directional sensitivity across oxygen levels. These findings suggest that distinct mechanisms govern the dynamic and directional components of dynamic cerebral autoregulation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42518515,

title = {Whole-brain biodistribution of AAV2, AAV8, and AAV-B10 after unilateral intracerebroventricular injection},

author = {Dezhuang Ye and Abhinav Kayithi and Jinyun Yuan and Isaac Wang and Tianqi Xu and Marc Boisvert and Marie-Eve Paquet and Hong Chen},

doi = {10.1016/j.omta.2026.201798},

issn = {3117-387X},

year  = {2026},

date = {2026-09-01},

journal = {Mol Ther Adv},

volume = {34},

number = {3},

pages = {201798},

abstract = {Adeno-associated virus (AAV) vectors represent promising tools for central nervous system (CNS) gene therapy; however, achieving efficient and widespread brain gene distribution while minimizing peripheral off-target exposure remains challenging. This study compares the brain and peripheral biodistribution patterns of three AAV serotypes, AAV2, AAV8, and AAV-B10, following intracerebroventricular (i.c.v.) administration in adult female mice. Using advanced tissue clearing methods with high-resolution light-sheet fluorescence microscopy, we visualized whole-brain AAV enhanced green fluorescent protein (eGFP) reporter distribution at single-cell resolution and employed semi-automated spatial quantification to analyze regional eGFP reporter signal. Each vector carried identical eGFP expression cassettes under the ubiquitous CAG promoter. AAV-B10 demonstrated superior parenchymal eGFP signal across multiple brain regions, with significantly higher expression in the cortex, midbrain, striatum, and thalamus compared to other serotypes. In contrast, AAV2 exhibited distinctive tropism for ventricular structures, with robust eGFP signal of ependymal cells lining the ventricular walls and choroid plexus. AAV8 showed intermediate eGFP distribution targeting the choroid plexus epithelium. Following i.c.v. administration, peripheral leakage of AAV genomes was observed, with AAV8 showing strong liver enrichment of eGFP transgene and AAV-B10 displaying broader yet weaker distribution across peripheral tissues. These serotype-specific distribution profiles provide critical insights for optimizing vector selection based on therapeutic requirements and target regions, potentially enhancing the efficacy of AAV-based gene therapies for neurological disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41699267,

title = {Genetic counseling services for hereditary breast and ovarian cancer: patients' experience and satisfaction with different service models},

author = {Ouerdia Haroun and Julie Lapointe and Rachel Guérard and Anne-Sophie Bergeron and Camille Raîche and Jocelyne Chiquette and Karine Bouchard and Marie-Pascale Pomey and Johanne Hébert and Gabrielle Olivier Chevrier and Philippe Lachapelle and Arian Omeranovic and Madeleine Côté and Lily Boily and Carmen Brisson and Jean Gekas and Tania Cruz-Marino and Omar Touhami and Arnaud Blanchet Saint-Pierre and Sylvain Gagnon and Karine Boisvert and Claire Brousseau and Lysanne Castonguay and Isabelle Gosselin and Marie-Claude Renaud and Maria-Gabriela Ruiz Mangas and Audrey Paquet-Beaupré and Marie-Eve Bélanger and Marie-Michelle Racine and Marie-Claude Roy and Sandra Blanchette and Valérie Faucher and Josianne Leblanc and Marie-Eve Dubeau and Mathias Cavaillé and Marie Plante and Christine Desbiens and Martin Beaumont and Jacques Simard and Michel Dorval and Hermann Nabi},

doi = {10.1038/s41431-026-02031-y},

issn = {1476-5438},

year  = {2026},

date = {2026-09-01},

journal = {Eur J Hum Genet},

volume = {34},

number = {9},

pages = {1384--1392},

abstract = {In the context of limited resources and growing demand, patients access genetic testing for hereditary breast and ovarian cancer (HBOC) through various service models, some of which include genetic counseling sessions. This study assessed the impact of these service models and participation in genetic counseling on patients' experiences and satisfaction with the genetic testing process. A total of 501 patients undergoing genetic testing for HBOC completed a 35-item survey, which included the Genetic Counseling Satisfaction Scale, the Decision Regret Scale, and a modified Royal Marsden Satisfaction Questionnaire. Additional information was gathered from the medical records. Descriptive statistics and Fisher's exact tests were employed for the analysis. Four aspects of the genetic testing experience differed between service models and attendance to genetic counseling: i) receipt of informational materials prior to testing, ii) information that additional discussions with the genetic team were possible, iii) clarity regarding the timeline for receiving results, and iv) explanation of how the results would be delivered. The service model and participation in genetic counseling seem to influence patients' experiences with genetic testing for HBOC. However, satisfaction was generally high and decision regret was low across all service models, highlighting the promise of care models designed to enhance accessibility.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42537557,

title = {Prenatal exposure to PM2.5 and infant health: Evidence from Quebec},

author = {Abdel-Hamid Bello and Maripier Isabelle and Guy Lacroix},

doi = {10.1016/j.ehb.2026.101631},

issn = {1873-6130},

year  = {2026},

date = {2026-09-01},

journal = {Econ Hum Biol},

volume = {62},

pages = {101631},

abstract = {We examine the effects of prenatal exposure to fine particulate matter (PM) on birth outcomes in a low-pollution setting. We combine administrative birth records in Quebec between 2008 and 2015 with air quality monitoring data and linked tax records in h neighborhood-by-quarter fixed effects models. While we find little evidence that prenatal PM exposure substantially affects birth outcomes on average at the population level, we unmask important heterogeneity. Constructing a cumulative socioeconomic vulnerability index, we find that in most vulnerable families a 1μg/m increase in average PM exposure is associated with a reduction of approximately 6.6 grams in birth weight. Focusing on a sample of births admitted to one of the province's neonatal care unit, we also find important effects of in utero PM exposure on biologically vulnerable newborns, both in terms of prematurity and of birth weight. We also find that days exceeding the Canadian 24-hour PM standard have disproportionately large effects among vulnerable families, such that peaks in exposure matter beyond average exposure itself.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42552826,

title = {Knowing Peter Killeen},

author = {Simon Grondin},

doi = {10.1002/jeab.70136},

issn = {1938-3711},

year  = {2026},

date = {2026-09-01},

journal = {J Exp Anal Behav},

volume = {126},

number = {2},

pages = {e70136},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42570684,

title = {A multi-approaches examination of toxicological effects of a naturally-occurring plant alkaloid veratridine, and the synthetic type II pyrethroid lambda-cyhalothrin on honey bees},

author = {Aklesso Kadala and Mercédès Charreton and Michel Pélissier and Jérôme Mutterer and Mohamed Chahine and Pierre Charnet and Claude Collet},

doi = {10.1016/j.etap.2026.105121},

issn = {1872-7077},

year  = {2026},

date = {2026-09-01},

journal = {Environ Toxicol Pharmacol},

volume = {126},

pages = {105121},

abstract = {Synthetic insecticides used in agriculture are one of the major causes for the loss of biodiversity. Naturally-occurring substances have been envisioned by agrochemical companies as environmentally-friendly alternatives. Here, the effects of the plant alkaloid veratridine and a synthetic pyrethroid insecticide, lambda-cyhalothrin, were compared on honey bees, using electrophysiology, ethology, and classical toxicology. Both compounds triggered strong deleterious effects, in vitro and in vivo. In cell-cultured antennal lobe neurons, their effects were qualitatively similar with the appearance of a persistent tail current through voltage-gated sodium channels. Veratridine-induced tail current had much slower kinetics. Both compounds caused mortality in a similar range of doses. At sublethal exposure levels, only lambda-cyhalothrin caused strong behavioral defects. This work could pave the way to updating the current safety assessment framework for insecticides, showing that in vitro assays can help in anticipating lethal and sublethal toxicity of both natural and synthetic compounds.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42617938,

title = {Postnatal sensory experience and barrel cortex alterations anticipate autistic traits in a mouse model of CDKL5 deficiency disorder},

author = {Alessandra Raspanti and Riccardo Pizzo and Antonia Gurgone and Cecilia Giraudo and Giulia Sagona and Andrea Macioce and Anthony Battaglia and Lamprini Katsanou and Debora Comai and Giorgio Medici and Francesco Ferrini and Tommaso Pizzorusso and Elisabetta Ciani and Maurizio Giustetto},

doi = {10.1016/j.pneurobio.2026.102949},

issn = {1873-5118},

year  = {2026},

date = {2026-09-01},

journal = {Prog Neurobiol},

volume = {264},

pages = {102949},

abstract = {Autistic traits may arise from atypical sensory experience during postnatal life, but whether there is a causal link between defects in cortical circuitry in the brain, altered sensory processing and social behavior remains unknown. Here, we studied tactile stimuli processing in the barrel cortex (BC) and social interactions in juvenile male mice lacking Cyclin-dependent kinase-like 5 (CDKL5), a model of a severe neurodevelopmental disease showing autistic traits and sensory impairments. We identified in these mice defects of whisker-dependent postnatal sensorimotor reflexes, NMDA receptors-dependent signaling, and dendritic orientation in thalamic inputs-receiving spiny stellate neurons. We also found that CDKL5 is required for mapping and processing whisker-derived tactile stimuli in the BC. Intriguingly, KO mice show autistic traits at P21 that are ameliorated by neonatal CDKL5 replacement in the BC. Our data suggest that CDKL5 is required to link tactile processing in the BC to the onset of social interaction abilities.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42643232,

title = {Region-specific weighting of sensory intensity and reward prediction error by dopamine signals},

author = {Sarah-Julie Bouchard and Joël Boutin and Martin Lévesque and Vincent Breton-Provencher},

doi = {10.1016/j.isci.2026.117130},

issn = {2589-0042},

year  = {2026},

date = {2026-09-01},

journal = {iScience},

volume = {29},

number = {9},

pages = {117130},

abstract = {Growing evidence shows that dopamine signaling is diverse, with dopaminergic neurons responding to rewarding and aversive stimuli. Here, we hypothesized that this heterogeneity arises from a distributed balance between two components of dopamine signaling: sensory intensity of a stimulus, and reward prediction error. To test this, we simultaneously recorded dopamine release across striatal and cortico-amygdalar circuits using multi-site fiber photometry and a fluorescent dopamine sensor during a classical conditioning paradigm. Using a regression model, we found that striatal areas such as the dorsal striatum and nucleus accumbens emphasized reward prediction error, whereas the medial prefrontal cortex and basolateral amygdala favored sensory intensity. Noise correlation analyses further supported these findings by revealing two modules of coordinated dopamine activity: one linking striatal regions and another linking cortical-amygdalar circuits. Together, our results suggest that dopamine balances sensory and reward information, a mechanism that may support attentional processes alongside its role in associative learning.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42717403,

title = {Listen to Africa: Nothing About Us Without Us},

author = {A Oyekola and C Ezeugwu and E Ndyareeba and Z Clay and A Blumenthal and C Cook and I Blanchette and C E Draper and B Milosavljevic and S Lloyd-Fox},

doi = {10.1177/17470218261490127},

issn = {1747-0226},

year  = {2026},

date = {2026-09-01},

journal = {Q J Exp Psychol (Hove)},

pages = {17470218261490127},

abstract = {[Formula: see text]Africa's 54 sovereign countries represent unparalleled linguistic, cultural and developmental diversities; however, structural inequities constrain representation and influence in global science. Within the field of child development and education, this shapes how studies are designed, interpreted and disseminated, often reinforcing deficit models of child development. In this opinion piece, our first aim is to identify barriers that limit opportunities for career development, global research output and policy innovation in this field. Our second aim is to identify African-led current solutions and priorities for the future. To enhance equitable representation, we draw on insights from a survey and knowledge-exchange workshops that included  = 60 researchers from 17 African countries who are part of the African Brain and Cognitive Development (AfriBCD) Network. Significant systemic and resource-based challenges that impact funding opportunities, career development and networking and infrastructure are identified. Current solutions to these challenges and priorities to drive further change range from investing in equitable partnerships, providing targeted early-career support, prioritising bidirectional capacity building and co-creating international funding agendas with African stakeholders. We argue for a paradigm shift that positions Africa as a global knowledge generator for child development and education, emphasising the collaborative principle of 'nothing about us without us'.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42703009,

title = {Rapid Generation of Functional Oligodendrocytes From Human Induced Pluripotent Stem Cells Through Small Molecule Guided Differentiation},

author = {Isabella Bienjonetti and Vincent Roy and Marie-Josée Beaudet and Aurélie Louit and Laurie Martineau and François Berthod and Nicolas Dupré and François Gros-Louis},

doi = {10.1002/jnr.70155},

issn = {1097-4547},

year  = {2026},

date = {2026-09-01},

journal = {J Neurosci Res},

volume = {104},

number = {9},

pages = {e70155},

abstract = {Oligodendrocytes (OLs) are essential for central nervous system (CNS) function through their role in axon myelination, and their dysfunction is implicated in a range of neurological disorders. Despite this, in vitro modeling of human OL biology remains limited by the scarcity of primary human OLs. Furthermore, while induced pluripotent stem cells (iPSCs) offer a promising source of human OLs, current differentiation protocols remain complex, inefficient, and time-consuming. Here, we present an optimized protocol to generate OLs from iPSCs (iOLs) using defined soluble factors supplemented in the culture media. Within 28 days, cultures yielded an average of 85% O4 iOLs, and by Day 38, approximately 70% expressed MBP, a key marker of mature OLs. Bulk RNA-seq analysis confirmed a stepwise transcriptional progression consistent with OL lineage identity, with upregulation of key OL-specific transcripts and gene expression profiles. Comparative transcriptomic analyses further revealed increased expression of gene networks associated with myelination, extracellular matrix remodeling, and gliogenesis when iOLs were cultured on aligned nanofiber scaffolds. Importantly, iOLs formed compact myelin sheaths around axons and showed enhanced maturation in a three-dimensional (3D) environment, highlighting the importance of spatial and matrix-derived cues in OL development. This study establishes a cost- and time-efficient approach for generating functional OLs from iPSCs, with broad applicability for disease modeling, drug screening, and the development of regenerative therapies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42733491,

title = {A remote and avatar-based approach for social cognitive impairments in psychotic disorders: A Canadian adaptation of RC2S},

author = {Elisabeth Thibaudeau and Elodie Peyroux and Nicolas Franck and Zelda Prost and Martin Lepage},

doi = {10.1016/j.scog.2026.100462},

issn = {2215-0013},

year  = {2026},

date = {2026-09-01},

journal = {Schizophr Res Cogn},

volume = {46},

pages = {100462},

abstract = {BACKGROUND: Social cognition is a core impairment in psychotic disorders and is strongly associated with functional outcomes. Although social cognitive training is effective, challenges remain regarding skill generalization and accessibility. This study aimed to develop culturally adapted French- and English-Canadian versions of RC2S and to assess the feasibility and acceptability of remote delivery.nnMETHODS: Fourteen individuals with a psychotic disorder were assessed at baseline, offered 24 twice-weekly RC2S sessions with a therapist over 12 weeks, and reassessed post-intervention. Motivation and therapeutic alliance were assessed through intra-session questionnaires. RC2S uses a personalized approach targeting social cognition and combines pen-and-paper exercises with digital relational simulations using avatars to promote skill transfer. Feasibility and acceptability were examined descriptively and paired-samples -tests assessed exploratory pre-post changes.nnRESULTS: All participants who initiated RC2S met the predefined completion criterion (≥50% of sessions), and all completed at least 75% of planned sessions (mean = 20.9). Acceptability was high for cultural adaptation, ease of use, and remote interaction (all>4.1/5), although ratings were lower for the RC2S interface (mean = 3.75/5). Motivation and therapeutic alliance remained high throughout the intervention (MUSIC>5.1;WAI > 4.3). Therapist support, perceived benefits, and remote accessibility were key facilitators. The largest exploratory pre-post changes occurred in therapist-administered goal attainment and functional impact measures. Findings from independently administered measures were more mixed, although a large change was observed for theory of mind.nnCONCLUSIONS: Findings support the feasibility and acceptability of remotely delivered, culturally adapted RC2S. Exploratory outcomes were mixed, requiring confirmation in a randomized trial with independent, blinded outcome assessment.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42424668,

title = {Psychedelics stores, their regulation and public health: knowledge, perceptions, attitudes and opinions of Canadians},

author = {François Gagnon and Anne Philibert and Benjamin Carignan and Elsa Labonté and Yannick Dufresne},

doi = {10.1016/j.drugpo.2026.105427},

issn = {1873-4758},

year  = {2026},

date = {2026-09-01},

journal = {Int J Drug Policy},

volume = {155},

pages = {105427},

abstract = {BACKGROUND: Psychedelic retail stores illegally selling psilocybin, DMT and related substances have proliferated in Canada, with close to 60 brick-and-mortar shops documented in 2023. This echoes the pre-legalization and regulation cannabis landscape. Public responses have remained inconsistent, oscillating between de facto tolerance and enforcement of the law, raising concerns among public health authorities and other stakeholders. How to regulate these stores has become a pressing policy question, yet no research has examined what Canadians know, perceive, and think about the stores and their regulation.nnMETHODS: A web-based survey of 3,674 Canadian adults was conducted in March 2025 via the Léger Opinion online panel. Descriptive and bivariate analyses examine knowledge, perceptions, and attitudes toward regulatory options and their associations with substance use, proximity to stores, and sociodemographic characteristics.nnRESULTS: Most respondents were unfamiliar with psychedelic stores (79.1%) or the products sold (80.3%). Among those with some familiarity, risk and benefit perceptions coexisted, with ambivalence being the most common configuration. Respondents were equally divided on closing the stores or maintaining the current unregulated status quo. By contrast, 66.6% supported authorization of sales by stores under a regulatory framework, including among respondents with no direct exposure to psychedelics. Large majorities favored public health protection over fiscal considerations, product restrictions, promotion limits, and caps on store numbers.nnCONCLUSION: Despite widespread unfamiliarity with psychedelic retail stores and ambivalent perceptions of their potential risks and benefits, Canadians appear more receptive to their authorization under a legal framework than to the status quo. Attitudinal ambivalence suggests that public support is not fixed and may be shaped by the features of the regulatory framework proposed.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42366279,

title = {Smooth emotional response: amygdalar neurovascular coupling drives stress encoding},

author = {Alice Cadoret and Luisa Bandeira Binder and Caroline Menard},

doi = {10.1038/s41422-026-01269-x},

issn = {1748-7838},

year  = {2026},

date = {2026-09-01},

journal = {Cell Res},

volume = {36},

number = {9},

pages = {639--640},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42837817,

title = {Expanding the toolbox of interventions for cannabis use disorder in individuals with first-episode psychosis: A pilot randomized controlled trial of iCanChange (iCC), a novel app-based psychological intervention},

author = {Selim Abou-Rahal and Ovidiu Tatar and Amal Abdel-Baki and Stephanie Coronado-Montoya and José Côté and Candice E Crocker and Jean-Gabriel Daneault and Pamela Lachance-Touchette and Clairélaine Ouellet-Plamondon and Marc-André Roy and Philip G Tibbo and Marie Villeneuve and Didier Jutras-Aswad},

doi = {10.1016/j.psychres.2026.117476},

issn = {1872-7123},

year  = {2026},

date = {2026-09-01},

journal = {Psychiatry Res},

volume = {367},

pages = {117476},

abstract = {Delivering face-to-face psychological interventions for cannabis use disorder (CUD) in early intervention services (EIS) for psychosis is often limited by structural barriers. App-based interventions may help overcome these limitations, though studies in non-psychosis populations report low engagement and retention. This study evaluated the feasibility of conducting an efficacy randomized controlled trial (RCT) of iCanChange (iCC), a novel app-based psychological intervention for CUD, and explored preliminary effects on cannabis use and related outcomes. We conducted a pilot RCT across 6 EIS programs in Canada, with 101 young adults aged 18-35 years with first-episode psychosis and CUD. They were randomized to modified EIS plus iCC (n = 51) or EIS only (n = 50). The intervention lasted 12 weeks with assessments at baseline and weeks 6, 12 (primary endpoint), and 24. Primary feasibility outcomes were intervention acceptability, defined as iCC completion (>50% of participants completing >50% modules), and trial retention, defined as >50% of participants retained at week 12. Secondary outcomes included cannabis use quantity and frequency, participant satisfaction, and app use metrics. Exploratory outcomes included cannabis-related outcomes, psychotic symptoms, and life satisfaction. Retention at week 12 was 84% in the intervention group and 86% in the control group, while iCC completion rate was 49% in intent-to-treat and 54% in per-protocol analyses. Preliminary signals of improvement in the intervention group were observed regarding cannabis use frequency, cannabis-related problems, dependence severity, and coping self-efficacy. Results demonstrate strong retention, supporting the feasibility of an efficacy trial while highlighting the need to enhance app engagement in youth with psychosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42811119,

title = {Comprehensive profiling of brain dynamics during anesthesia across phylogeny},

author = {Andrea I Luppi and Lynn Uhrig and Jordy Tasserie and Golia Shafiei and Antoine Légaré and Kanako Muta and Junichi Hata and Hideyuki Okano and Daniel Golkowski and Andreas Ranft and Rudiger Ilg and Denis Jordan and Silvia Gini and Zhen-Qi Liu and Yohan Yee and Pablo Castro and Camilo M Signorelli and Rodrigo Cofre and Alain Destexhe and David K Menon and Emmanuel A Stamatakis and Patrick Desrosiers and Paul De Koninck and Christopher W Connor and Alessandro Gozzi and Ben D Fulcher and Bechir Jarraya and Bratislav Misic},

doi = {10.1038/s41593-026-02460-4},

issn = {1546-1726},

year  = {2026},

date = {2026-09-01},

journal = {Nat Neurosci},

abstract = {The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features. This reveals a conserved dynamical profile of anesthesia across species, characterized by shorter intrinsic timescales of neural activity and dampened inter-regional synchrony. Deep-brain stimulation of the macaque centromedian thalamus reverses this profile and restores behavioral responsiveness. This conserved dynamical phenotype covaries with conserved transcriptional profiles of excitatory and inhibitory neurotransmission. Biophysical modeling provides a potential mechanistic link between the macroscale dynamical phenotype of anesthesia and microscale effects of key molecular targets on the timescales of synaptic excitation and inhibition. These analyses reveal a shared neural endpoint of anesthesia: across species and scales, anesthetics induce spatiotemporal isolation of local neural activity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42803645,

title = {Mu suppression reveals auditory-motor predictions after short musical training},

author = {Oscar Bedford and Alberto Ara and Jérémie Ginzburg and Philippe Albouy and Robert J Zatorre and Virginia B Penhune},

doi = {10.1093/cercor/bhag118},

issn = {1460-2199},

year  = {2026},

date = {2026-09-01},

journal = {Cereb Cortex},

volume = {36},

number = {9},

abstract = {Auditory-motor coupling is a bidirectional neural mechanism that supports speech and music, as evidenced by motor system activation during passive listening to both spoken language and learned melodies. Such activation is anticipatory, occurs in non-musicians, and can be elicited at the single-note level. These prior findings support the idea that motor activity guides auditory perception by relaying predictive timing information. However, the neural processes underlying this kind of motor activity are not fully understood. Electroencephalography studies in musicians have linked it to mu-band suppression, but the temporal scale and the generalizability to the broader population remain unclear. We recruited 25 non-musicians who learned to play a simple melody on a piano-like keyboard. Before and after training, participants passively listened to the trained melody and control melodies. Offline, electroencephalography data from the motor training were used to generate a time-frequency mask with which to identify mu suppression occurring during passive listening. Significant mu suppression emerged before each note only during post-training exposure to the practiced melody. These results suggest that mu suppression occurs at the single-note level following short motor training and is not dependent on prior musical experience. Our findings support the notion that motor activity aids perception by anticipating the unfolding of learned auditory-motor sequences.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42762303,

title = {Pain Overexposure Affects Self-Pain and Empathy in Athletes},

author = {Audrey Marcoux and Camille Rouleau and Marie-Hélène Tessier and Elliot Gagner and Marie-Pier B Tremblay and Philip L Jackson},

doi = {10.1177/00332941261488359},

issn = {1558-691X},

year  = {2026},

date = {2026-09-01},

journal = {Psychol Rep},

pages = {332941261488359},

abstract = {Experiencing pain repeatedly or over prolonged periods has been shown to affect the pain experience itself. Similarly, people overexposed to others' pain respond differently to expressions of it. Given that pain experience and empathy toward others' pain share cognitive and cerebral mechanisms, examining how both are affected by overexposure to self-pain and others' pain within the same population is of particular interest. Athletes represent one such population. This study thus aimed to compare pain perception and empathy in athletes and non-athletes. Thirty athletes and 28 non-athletes were asked to imagine their pain in different contexts and report its intensity and unpleasantness, assess the intensity and unpleasantness of others' pain, and report their felt empathy for pain. They also completed questionnaires on pain, sports experiences, and trait empathy. The main results show that athletes reported similar pain intensity but less unpleasantness for their own pain than non-athletes, comparable intensity and unpleasantness for others' pain, and less empathy specifically for facial expressions depicting high pain. Together, these findings suggest reduced affective responding rather than changes in the sensory perception of pain. Several sport-specific mechanisms may explain these reductions, including greater habituation, stronger beliefs about pain controllability, regulatory flexibility, and the possibility that more sport-relevant contexts are required to fully engage athletes' propensity for empathy. This study contributes to a better understanding of the complex relationship between repeated pain experience and empathy toward that state in others.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42743935,

title = {Accuracy of type 2 inflammatory biomarkers to diagnose asthma in adults and children: a meta-analysis of 30 studies with prospective validation in an adult primary care cohort},

author = {Marc-André Roy and Morgane Gronnier and Laurence Désy and Lauranne Pouliot and Samuel Lemaire-Paquette and Sarah-Ève Lemieux and Manisha Ramphul and Félix-Antoine Vézina and Philippe Lachapelle and Martine Duval and Mathieu Belzile and Jianghua Li and Yong He and Florence Schleich and Mare Sabbe and Jose Luis Lopez-Campos and Belen Muñoz-Sanchez and Francisco Javier Alvarez-Gutierrez and Auxiliadora Romero-Falcon and Javier Mallol and Asger Sverrild and Marina Lluncor Salazar and Krzysztof Kowal and Vibeke Backer and Antonius Schneider and Andréanne Côté and Francine M Ducharme and Erol A Gaillard and Simon Couillard},

doi = {10.1016/S2213-2600(26)00228-6},

issn = {2213-2619},

year  = {2026},

date = {2026-09-01},

journal = {Lancet Respir Med},

abstract = {BACKGROUND: Asthma diagnosis is challenging, partly due to low yield of bronchodilator reversibility and limited access to bronchial provocation tests (BPTs). Fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC) have been proposed as rule-in biomarkers. We aimed to evaluate the diagnostic accuracy of these biomarkers in adults and children, focusing on primary care applicability.nnMETHODS: In this systematic review and meta-analysis, we searched MEDLINEand other databases from inception to June 4, 2024, for eligible diagnostic studies (randomised trials, cohort, cross-sectional, case-control, or case series). We included studies comparing FeNO or BEC with BPT or bronchodilator reversibility plus BPT in patients aged 5 years or older with suspected asthma and normal spirometry. Diagnostic performance in adults (aged ≥18 years) and children (aged 5-17 years) was estimated by the primary outcome measure of area under the receiver operating characteristic curve (AUC). Rule-in thresholds (prespecified) and rule-out thresholds (post hoc) were derived. In a single-centre cohort study (DIVE), analyses were prospectively replicated in bronchodilator reversibility-negative individuals referred for a BPT by primary care. Patients underwent FeNO and BEC immediately before a standardised methacholine BPT. The primary outcome for DIVE was biomarker performance for positive BPT, ascertained by AUC for FeNO, BEC, and the combination of FeNO and BEC. Post-hoc analyses addressed potential confounding by inhaled corticosteroid exposure. The systematic review and meta-analysis was registered with PROSPERO (CRD42023489738). The DIVE study was registered with ClinicalTrials.gov (NCT05592519).nnFINDINGS: 22 adult studies with 7141 patients and nine paediatric studies with 989 patients were included for meta-analysis (30 studies overall, with one study in both adults and children). FeNO diagnostic accuracy was good in adults (AUC 0·80 [95% CI 0·73-0·85]) and fair in children (0·75 [0·65-0·82]). In adults, FeNO of 48 ppb or higher achieved a positive likelihood ratio of 10·1 (95% CI 8·9-11·2). At a 20% prevalence reflecting primary care, a FeNO of 65 ppb or higher achieved a positive predictive value (PPV) of 80% (95% CI 72-86), and FeNO of less than 20 ppb achieved a negative predictive value of 93% (91-94) with 18% (12-25) missed diagnoses. In children, at the 56% aggregated study prevalence, FeNO of 30 ppb or higher achieved a PPV of 80% (95% CI 73-84). In adults, BEC showed weak stand-alone accuracy (AUC 0·65 [95% CI 0·59-0·71]) and added no value to FeNO. The DIVE cohort study (22 [18%] of 123 patients BPT positive) validated results of the meta-analysis in adults, with similar AUCs (0·77 [95% CI 0·65-0·89] for FeNO alone and 0·67 [0·53-0·80] for BEC alone). FeNO thresholds correctly classifyied rule-in decisions (FeNO >65 ppb: PPV 73% [95% CI 39-94]) and rule-out decisions (FeNO <20 ppb: NPV 92% [82-97]) with 89% overall accuracy. In both the meta-analysis and the DIVE cohort, FeNO diagnostic accuracy declined within 2 weeks of inhaled corticosteroid exposure.nnINTERPRETATION: In adults and children with suspected asthma, FeNO predicted airway hyper-responsiveness and enabled clinically applicable rule-in and rule-out thresholds. BEC performed poorly alone and added no value to FeNO. Findings and thresholds were replicated in a prospective adult primary care cohort; a similar study in children is ongoing. FeNO-guided diagnostic algorithms using context-specific rule-in and rule-out thresholds, while accounting for recent inhaled corticosteroid exposure, warrant consideration.nnFUNDING: Fonds de Recherche du Québec-Santé, Association Pulmonaire du Québec, Québec Ministry of Health and Social Services, AstraZeneca, Opération Enfant Soleil, and NIOX Group.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42731569,

title = {Detecting dynamic pathways and risk indicators of resilience, vulnerability and stability in normally aging females and males: Integrating data-driven longitudinal and machine learning analyses},

author = {Shannon M Drouin and Olivier Potvin and Harrison Fah and Kaarin J Anstey and Mario Masellis and Simon Duchesne and Roger A Dixon and },

doi = {10.1016/j.neurobiolaging.2026.09.002},

issn = {1558-1497},

year  = {2026},

date = {2026-09-01},

journal = {Neurobiol Aging},

volume = {169},

pages = {37--54},

abstract = {Resilience has become an integral component of theory and research in brain aging. Recent frameworks have provided guidelines for identifying and investigating resilience in the context of diversity (e.g., sex and risk exposure differences). We leverage a multi-factorial longitudinal approach to operationalize and predict pathways of resilience, stability and vulnerability as a function of differential within-person trajectory patterns of hippocampal volume and cognitive change. Participants included cognitively unimpaired (at baseline) older adults (n = 415; M age = 74.9; 59.9% Female) from the Alzheimer's Disease Neuroimaging Initiative with longitudinal imaging and cognition data, plus multimodal risk indicators. We used latent class growth analyses to identify hippocampal and cognitive trajectory classes. Machine learning applications identified risk indicators associated separately by pathway in the entire sample and disaggregated by sex. Based on differential combined class membership, we identified three subgroups: resilience (declining hippocampal/stable cognitive trajectories), stable (stable hippocampal/stable cognitive trajectories), vulnerable (stable hippocampal/declining cognitive trajectories). Leading risk indicators of resilience (e.g., lower plasma Aβ1-42) and vulnerability (e.g., lower education) originated from the biological and demographic domains. Leading risk indicators of stability originated from the biological and genetic domains (e.g., higher CSF Aβ1-42, lower polygenic hazard score). Sex-disaggregated results highlighted indicators unique to the females, such as higher body mass index (stability) and lower geriatric depression score (stability, vulnerability). Pathway patterns of resilience, stability and vulnerability were characterized objectively in initially cognitively unimpaired older adults based on specified hippocampal and cognitive trajectory combinations. Risk factors from a broad range of modalities should be considered in future research.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42721556,

title = {A structured framework for human-AI resemblance: Evidence, inference and perception},

author = {Peng Wang and Effie Lai-Chong Law and Liye Zou and Yi Jiang and Ralph Hertwig and Fred Paas and Steven Laureys},

doi = {10.1016/j.plrev.2026.09.003},

issn = {1873-1457},

year  = {2026},

date = {2026-09-01},

journal = {Phys Life Rev},

volume = {59},

pages = {76--93},

abstract = {Artificial intelligence is increasingly encountered not as background software but as an interlocutor, adviser and institutional gatekeeper. Yet claims that an AI system is 'human-like' often collapse distinct comparison targets, measurements and inferences into a single label. This Review proposes a structured framework in which every resemblance claim specifies the human reference class, the AI system and version, the task and context, the property compared, the measurement relation, the perturbations considered, the uncertainty of the estimate and the inference that the evidence permits. Four recurring evidence families concern behavioural outputs, representational organization, process dynamics and neural or physiological correspondence. Perceived resemblance is treated separately as an observer attribution that can mediate trust, reliance, disclosure, delegation and moral concern. We distinguish exact from approximate resemblance, symmetric from directional measures, static from dynamical correspondence and observational from interventional evidence. Worked examples show how to code missing or conflicting indicators without forcing them into a single score. Convergence supports broader conclusions only when measures with different assumptions exclude distinct alternatives; otherwise, agreement may reflect shared data, stimuli, objectives or mappings. The framework is intended both for exploratory science and for application-matched evaluation, while preserving strict limits on claims about cognition and consciousness.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42142824,

title = {Clinical features of central sensitization moderate the effect of repetitive transcranial magnetic stimulation in chronic low back pain},

author = {Philippe Patricio and Jean Tittley and Fábio Carlos Lucas de Oliveira and Mathieu Roy and Luciana G Macedo and Jean-Sébastien Roy and Hugo Massé-Alarie},

doi = {10.1016/j.jpain.2026.106317},

issn = {1528-8447},

year  = {2026},

date = {2026-08-01},

journal = {J Pain},

volume = {45},

pages = {106317},

abstract = {This secondary analysis of a randomized controlled trial investigated whether baseline clinical characteristics moderate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and motor control exercise (MCE) for chronic low back pain (CLBP). One hundred and forty participants were randomized to active or sham rTMS treatment, combined with or without MCE. Six potential effect modifiers (sex, kinesiophobia, self-efficacy, central sensitization features, lumbar instability, and expectation) were assessed at baseline. Linear mixed models tested interaction effects on pain and disability outcomes at 8 weeks following randomization. A significant interaction was found between rTMS and Central Sensitization Inventory (CSI) scores for disability (p = 0.039): participants with high CSI scores (≥ 40) who received active rTMS had worse disability compared to (i) those with high score who received a sham (mean difference 5.66; 95% CI 0.11-11.21), and (ii) those with low CSI scores who received active rTMS (mean difference -7.28; 95% CI, -12.06 to -2.50). No effect modifiers were identified for MCE. Independent of treatment allocation, positive expectations, lower CSI scores, and higher self-efficacy predicted better disability outcomes. Contrary to the initial hypothesis, active rTMS may hinder recovery in CLBP patients with clinical features of central sensitization. If confirmed, CSI screening could inform personalized brain stimulation strategies to avoid detrimental effects. No evidence supported subgroup-specific benefits of MCE. PERSPECTIVE: This article shows that, when compared to sham stimulation, rTMS may attenuate disability improvement in participants with chronic low back pain who exhibit symptoms of central sensitization. If confirmed, these findings highlight the moderating role of sensitization mechanisms and may guide future personalized neuromodulation approaches.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42635511,

title = {Switching between pairwise and higher-order synchronization on simplicial complexes},

author = {Prejaas K B Tewarie and Steven Laureys and Rikkert Hindriks},

doi = {10.1063/5.0343072},

issn = {1089-7682},

year  = {2026},

date = {2026-08-01},

journal = {Chaos},

volume = {36},

number = {8},

abstract = {Most complex systems, from the brain to ecosystems and multi-agent networks, display pairwise and higher-order interactions that determine their collective behavior. Yet, the regimes in which one interaction order dominate over another, and the mechanisms by which systems move between such regimes remain poorly understood analytically. Here, we consider a network of coupled Stuart-Landau oscillators on time-varying simplicial complexes, for which both pairwise and triplet interactions play a role in phase synchronization. We apply phase reduction and mean-field theory to obtain a reduced model that incorporates structural information through graph and Hodge Laplacians. This results in an analytic formula for a critical coupling surface that delineates regimes of dominance of pairwise- or triplet-mediated synchrony. To quantify how the prevailing synchronization mechanism changes over time, we define an interaction dominance index and investigate how slow modulation of coupling intensities gives rise to regime transitions between pairwise- and triplet-mediated synchrony. Our results provide a tractable framework for understanding how topology and time-dependent coupling jointly control regime switching in systems with coexisting interaction orders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42190300,

title = {The intelligent ear: AI and hearing aids information seeking and users' discussion on social media},

author = {Joanie Ferland and Ariane Blouin and Matthieu J Guitton and Andréanne Sharp},

doi = {10.1016/j.pec.2026.109703},

issn = {1873-5134},

year  = {2026},

date = {2026-08-01},

journal = {Patient Educ Couns},

volume = {149},

pages = {109703},

abstract = {OBJECTIVES: Hearing aids are the primary technology used to compensate for hearing loss, yet conventional signal treatment algorithms often fall short of providing optimal performance in noisy situations. The rise of Artificial Intelligence (AI) is opening new avenues for more powerful hearing aids. However, information available for patients regarding AI and hearing aids is scarce. The purpose of this study was to evaluate the availability of online information on AI-enhanced hearing aids for patients, focusing on the social media platform Reddit.nnMETHODS: Data were collected on October 1st 2023 following the use of pre-determined keywords. Based on a final sample of 5046 comments distributed amongst 378 threads, the main topics of interest related to AI and hearing aids discussed by users (including patients, relatives and hearing health professionals) were identified.nnRESULTS: Out of 43,376 threads generated by our searches, 2678 were relevant to the topic of AI in hearing aids. Interestingly, a strong involvement of hearing health professionals was evidenced within the platform, with 52.1% self-identifying as such in some sub-communities (e.g.,r/audiology). In each user group, AI accounted for 3.3% or less of discussion topics, with most conversations instead focusing on practical aspects such as programming, physical features, costs, and connectivity.nnCONCLUSIONS: Overall, this study demonstrates both the potential and the limits of social media platforms as vectors for patient information on AI-derived medical devices, by identifying the paucity of information useable by uninformed patients, and emphasising the need for digital literacy, patient education.nnPRACTICE IMPLICATIONS: Social media discussions are useful vectors to inform healthcare professionals about their patient's concerns. More research is required to assess the quality of information shared online, however, professionals' presence in social media interaction with patients is essential to improve the accuracy of provided information.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42399454,

title = {GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling},

author = {Imane Hadj-Aissa and Maéline Muller and Jorge Soliz and Chantelle F Sephton and Paul A Dutchak},

doi = {10.1038/s44319-026-00846-w},

issn = {1469-3178},

year  = {2026},

date = {2026-08-01},

journal = {EMBO Rep},

volume = {27},

number = {15},

pages = {4252--4271},

abstract = {GATOR1 is an evolutionarily-conserved negative regulator of mTORC1-dependent signal transduction with pathogenic mutations linked to epilepsy, infantile spasms, and autism spectrum disorders. While a biochemical role of GATOR1 in amino acid-signaling is established, its cell-type specific contributions within the brain remain poorly defined. Here, we show that loss of GATOR1 function in astrocytic cells disrupts mitochondrial metabolism, with a selective dysfunction of the electron transport chain Complex II leading to elevated reactive oxygen species (ROS) and redox imbalance. These changes are accompanied by compensatory increases in antioxidant regulatory systems including superoxide dismutase, but remain insufficient to ameliorate the increased ROS. GATOR1-deficient astrocytes show metabolic rewiring marked by enhanced expression of glutamate uptake and glutamine synthesis pathways that contribute to the glutamate-glutamine cycle governing neuronal glutamine availability and synaptic homeostasis. In vivo, GATOR1 deficiency results in progressive astrocytic reactivity, seizures, and a reduced lifespan. These findings demonstrate that GATOR1 function is critical to coordinate astrocytic mitochondrial activity and neurotransmitter cycling pathways, establishing a novel link between intracellular amino acid-signaling in astrocytes and excitatory neural network homeostasis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42235368,

title = {Generation of a lymphoblastoid-derived induced pluripotent stem cell line (CBRCULi021-A) from a healthy donor for disease modeling},

author = {Cyrielle Jajkiewicz and Mohamed Chahine},

doi = {10.1016/j.scr.2026.104020},

issn = {1876-7753},

year  = {2026},

date = {2026-08-01},

journal = {Stem Cell Res},

volume = {94},

pages = {104020},

abstract = {Human induced pluripotent stem cells (hiPSCs) provide a versatile platform for studying cellular physiology, developmental biology, and therapeutic approaches. Here, we report the generation and characterization of a control lymphoblastoid-derived hiPSC line (CBRCULi021-A) from a healthy donor. This hiPSC line displays typical colony morphology, robust expression of pluripotency markers, the ability to differentiate into all three embryonic germ layers, and no chromosomal abnormalities detected by aCGH analysis. In addition, the line was free of residual reprogramming vectors. CBRCULi021-A represents a well-characterized control resource for comparative studies and disease modeling applications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41139714,

title = {Testing the Transportability of the Psychosis Metabolic Risk Calculator in Canada (Quebec): International External Validation Study},

author = {Sébastien Brodeur and Olivier Corbeil and Laurent Béchard and Maxime Huot-Lavoie and Charles Desmeules and Dominic Oliver and Andrea De Micheli and Emanuele F Osimo and Rachel Upthegrove and Golam M Khandaker and Graham K Murray and Fanny Lajeunesse-Trempe and Gloria Cheung and Josiane Courteau and Chantale Thériault and Marc-André Roy and Marie-France Demers and Benjamin I Perry},

doi = {10.1093/schbul/sbaf174},

issn = {1745-1701},

year  = {2026},

date = {2026-08-01},

journal = {Schizophr Bull},

volume = {52},

number = {5},

abstract = {BACKGROUND AND HYPOTHESIS: Cardiometabolic morbidity largely explains premature mortality in people with psychotic disorders and is detectable from psychosis onset. Currently, no accurate cardiometabolic risk prediction tool exists for young people with first-episode psychosis (FEP). The Psychosis Metabolic Risk Calculator (PsyMetRiC) aims to bridge this gap, but its accuracy and potential clinical usefulness in North American populations remain unverified.nnSTUDY DESIGN: The external validity of PsyMetRiC, developed in the United Kingdom to predict the risk of incident metabolic syndrome (MetS) up to 6 years after a FEP, was assessed using the data from the Quebec Psychosis Early Intervention Clinic. PsyMetRiC comprises 2 penalized logistic regression models: a full-model including age, sex, ethnicity, body mass index (BMI), smoking status, prescription of metabolically-active antipsychotic medication, high-density lipoprotein (HDL), and triglyceride concentrations; and a partial-model excluding biochemical predictors. Patients aged 16-35 years, diagnosed with FEP between 2004 and 2023 without pre-existing MetS, and with>12 months follow-up were included. Predictive performance of PsyMetRiC was assessed by discrimination (C-statistic), calibration (calibration plots), and clinical usefulness (decision curve analysis). The race and ethnicity predictor was refined to better represent the North American population.nnSTUDY RESULTS: Among 559 included patients (mean age 24.1 years ±4.1; 22.5% female), 18.2% developed MetS during a mean follow-up of 1.7 ± 1.3 years. Compared with the UK development cohort, the Canadian sample exhibited a higher BMI, lower HDL cholesterol, lower triglycerides, lower blood glucose, and lower systolic blood pressure. Discrimination performance was acceptable (full model C = 0.74, 95% CI, 0.70-0.77; intercept = 0.225; slope = 1.278; partial model C = 0.70, 95% CI, 0.67-0.74; intercept = -0.555; slope = 0.993). After updating the model with a race and ethnicity predictor calibrated to locally representative categories, performance improved slightly (full model C = 0.74, 95% CI, 0.71-0.77; intercept = 0.000; slope = 1.001; partial model C = 0.71, 95% CI, 0.68-0.74; intercept = 0.001; slope = 1.005).nnCONCLUSIONS: This study provides the first external validation of PsyMetRiC in a North American sample. Further research is essential before routine clinical implementation, but PsyMetRiC offers promise as a tool for early detection of cardiometabolic risk in early psychosis, guiding personalized treatments to diminish long-term physical health impacts.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42026225,

title = {Phage host range: determinants, dynamics and applications},

author = {Audrey Leprince and Vincent Somerville and Audrey A Addablah and Carlee Morency and Sylvain Moineau},

doi = {10.1038/s41579-026-01306-x},

issn = {1740-1534},

year  = {2026},

date = {2026-08-01},

journal = {Nat Rev Microbiol},

volume = {24},

number = {8},

pages = {518--538},

abstract = {Determining the host range is a fundamental step in characterizing newly isolated phages, as it not only guides their use in therapy and in biocontrol applications but also helps in managing their impact on bioprocesses. Host specificity is typically evaluated through experimental assessment of host cell lysis, but the underlying molecular mechanisms that define host range are rarely explored in a comprehensive manner. Interactions between viral proteins and bacterial surface receptors during adsorption have historically been viewed as the primary determinants of host specificity. However, advances in cataloguing the diversity of bacterial defence systems emphasize that host range is shaped by a complex interplay of phage-host interactions, phage-phage interactions and environmental factors. Moreover, host range is dynamic, being influenced by ongoing coevolution between phages and bacteria as well as by phenotypic variability. As tools are now being developed to predict phage host range at the strain level from genomic data, a deep understanding of the diverse, dynamic factors that shape this host range is essential. In this Review, we provide an integrated perspective on the molecular and ecological determinants of phage host range, explore their dynamics and discuss the implications for phage-based applications.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42097472,

title = {Trajectories of pain and key predictors in two years of chronic low back pain: A prospective longitudinal cohort study},

author = {Pouya Rabiei and Michel-Pierre Coll and Pierre Langevin and Marc-Olivier Dubé and Jean-Sébastien Roy and Hugo Massé-Alarie and },

doi = {10.1016/j.jpain.2026.106310},

issn = {1528-8447},

year  = {2026},

date = {2026-08-01},

journal = {J Pain},

volume = {45},

pages = {106310},

abstract = {Chronic low back pain (CLBP) is prevalent. Understanding its progression and identifying related predictors is essential to guide its management. This study aimed to characterize CLBP trajectories over two years and identify baseline predictors of these trajectories. Data from 2713 participants enrolled in the Quebec Low Back Pain Study were analyzed. This cohort represents the analytic sample drawn from a larger cohort (n= 3894) where 30.3% (n = 1181) were excluded due to missing follow-up data. Baseline variables were collected using the Canadian adaptation of NIH Minimum Dataset. Pain intensity (0-10 scale) was assessed at 3, 6, 12, and 24 months after enrollment. Latent Class Growth Analysis (LCGA) was used to identify pain trajectories, and machine learning classifiers were trained to determine baseline predictors of trajectory membership. LCGA revealed moderate stable pain (40%), mild stable pain (30%), high persistent pain (16.4%), and gradually improving pain (14.6%) clusters. Most individuals with CLBP experienced stable pain, whereas gradually improving pain cluster showed clinically meaningful improvement (mean pain intensity: from 4.08 to 2.10 over two years). In all clusters key prognostic factors included pain intensity, pain interference, physical disability, and catastrophizing. Higher levels of these factors were associated with increased likelihood of membership in higher-pain trajectories, whereas lower levels were associated with lower-pain trajectories. Some factors were unique to each cluster; younger age, lower sleep disturbance, and shorter pain duration were associated with the gradually improving pain trajectory. These findings should be interpreted cautiously given the exclusion of participants with missing follow-ups. PERSPECTIVE: Our analyses of a large cohort of CLBP identified four trajectories: high persistent pain, moderate stable pain, mild stable pain, and gradually improving pain over a two-year period. The most influential factors associated with each trajectory help to better understand the characteristics associated with pain stability or improvement over time.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid42208097,

title = {Heatwrap and exercise in acute low back pain: a multi-arm randomised controlled trial},

author = {Claudia Côté-Picard and Jean Tittley and Catherine Mailloux and Amélie Desgagnés and Kadija Perreault and Catherine Mercier and Clermont E Dionne and Jean-Sébastien Roy and Hugo Massé-Alarie},

doi = {10.1016/j.msksp.2026.103587},

issn = {2468-7812},

year  = {2026},

date = {2026-08-01},

journal = {Musculoskelet Sci Pract},

volume = {84},

pages = {103587},

abstract = {BACKGROUND: Superficial heat is recommended in acute low back pain (LBP) to reduce pain and disability. Exercise is recommended in chronic LBP, but its relevance in acute LBP remains debated. Heatwrap could potentiate the effect of exercise in acute LBP, and this combination might help preventing the transition to chronic pain.nnOBJECTIVE: To compare the effect of heatwrap alone or combined with exercise to a sham heatwrap on disability at short-, mid- and long-term in acute LPB.nnDESIGN: A multi-arm randomised controlled trial with follow-ups at 1, 4, 12, 26 and 52 weeks took place at a research center in Québec City, Canada. Out of 315 interested individuals, 99 adults with acute LBP were recruited. Participants were assigned to one of three groups for a 7-day intervention: Heatwrap plus exercise (n = 34), heatwrap alone (n = 33) or sham heatwrap (n = 32). The main outcome was pain-related disability measured at one week with the Oswestry Disability Index (0 to 100; higher scores imply more disability).nnRESULTS: At one week, heatwrap plus exercise was not better than heatwrap alone (mean difference (MD) -1.6 [95% CI -6.2 to 3.0]) or sham heatwrap (MD -0.5 [95% CI -5.0 to 4.2]). Likewise, heatwrap alone had no effect compared to sham heatwrap (MD 1.2 [95% CI -3.4 to 5.8]).nnCONCLUSIONS: A combination of heatwrap and exercise was not statistically superior to heatwrap alone or a sham heatwrap in the treatment of acute LBP, contrasting with the existing literature and guidelines.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}